Sulfo-SMCC交联剂(水溶性)(92921-24-9)

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产品名称：Sulfo-SMCC交联剂(水溶性)
英文名称：Sulfo-SMCC crosslinker
产品货号：GS4332
产品规格：50mg

CAS号：92921-24-9
EINECS号：999-999-2
分子量：436.4
储存条件：冷冻（-20℃）

概述

SMCC and its water-soluble analog Sulfo-SMCC are heterobifunctionalcrosslinkers that contain N-hydroxysuccinimide
(NHS)ester and maleimide groups that allow covalent conjugation of amine- and sulfhydryl-containing molecules.NHS
esters react with primary amines at pH 7~9 to form amide bonds,while maleimides react with sulfhydryl groups at pH
6.5~7.5 to form stable thioether bonds.In aqueous solutions,NHS ester hydrolytic degradation is a competing reaction
whose rate increases with pH.The maleimide group is more stable than the NHS-ester group but will slowly hydrolyze and
loses its reaction specificity for sulfhydryls at pH values>7.5.For these reasons,conjugations with these crosslinkers are
usually performed at pH 7.2~7.5,with the NHS-ester(amine-targeted)reacted before or simultaneous with the maleimide
(sulfhydryltargeted)reaction.

应用

Sulfo-SMCC is soluble in water and many other aqueous buffers to approximately 10mM,although solubility decreases

组份

50mg/bottle

技术规格
 

分子量	436.37
间隔臂	8.3?
纯度	＞98%on TLC
Net Mass Added	219.09

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