MBS交联剂(不溶于水)(58626-38-3)

特别提示：包括MBS交联剂(不溶于水)在内，本公司的所有产品仅可用于科研实验，严禁用于临床YL及其他非科研用途！

产品名称：MBS交联剂(不溶于水)
产品货号：GS4329
产品规格：50mg

CAS号：58626-38-3
EINECS号：999-999-2
分子量：314.2
储存条件：冷冻（-20℃）

概述

MBS and its water-soluble analog Sulfo-MBS are heterobifunctional cross-linkers that contain N-hydroxysuccinimide(NHS)
ester and maleimide groups that allow covalent conjugation of amine- and sulfhydryl-containing molecules.NHS esters
react with primary amines at pH 7-9 to form amide bonds,while maleimides react with sulfhydryl groups at pH 6.5-7.5 to
form stable thioether bonds.In aqueous solutions,hydrolytic degradation of the NHS ester is a competing reaction whose
rate increases with pH.The maleimide group is more stable than the NHS-ester group but will slowly hydrolyze and also
lose its reaction specificity for sulfhydryls at pH values>7.5.For these reasons,conjugation experiments involving these
cross-linkers are usually performed at pH 7.2-7.5,with the NHS-ester(amine-targeted)reaction being accomplished before
or simultaneous with the maleimide(sulfhydryl-targeted)reaction.

应用

MBS is not directly water-soluble and must be dissolved first in an organic solvent such as dimethylsulfoxide(DMSO)or dimethylformamide(DMF);subsequent dilution into aqueous reaction buffer is generally possible,and most protein reactants will remain soluble if the final concentration of organic solvent is less than 10%.

组份

50mg/bottle

技术规格
 

分子量	314.25
间隔臂	7.3?
纯度	＞95%on TLC

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