Mouse BCMA / TNFRSF17 Protein, Fc Tag

内毒素:
Less than 1.0 EU per μg by the LAL method.

纯度:
>95% as determined by SDS-PAGE.

活性:
Measured by its binding ability in a functional ELISA. Immobilized Mouse BAFF, Mouse IgG2a Fc Tag at 5 μg/mL (100 μL/well) can bind Mouse BCMA, Fc Tag (Cat. No. BCA-M5258) with a linear range of 2-20 ng/mL (QC tested).

产品背景:
Tumor necrosis factor receptor superfamily member 17 (TNFRSF17) is also known as B-cell maturation protein (BCMA), CD antigen CD269, which is a member of the TNF-receptor superfamily. TNFRSF17 contains one TNFR-Cys repeat. TNFRSF17 is expressed in mature B-cells, but not in T-cells or monocytes. TNFRSF17 is receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. TNFRSF17 promotes B-cell survival and plays a role in the regulation of humoral immunity. TNFRSF17 can activate NF-kappa-B and JNK.

产品描述:
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 32.1 kDa. The protein migrates as 36 kDa under reducing (R) condition (SDS-PAGE) due to O-linked glycosylation which has been verified by O-Glycosidase and Neuraminidase digestion.
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