Biotinylated Bovine FcRn / FCGRT & B2M Heterodimer Protein

内毒素:
Less than 1.0 EU per μg by the LAL method.

纯度:
>90% as determined by SDS-PAGE.

活性:
Measured by its binding ability in a functional ELISA. Immobilized Ipilumimab at 2 μg/mL (100 μL/well) can bind Biotinylated Bovine FcRn Heterodimer Protein (Cat. No. FCN-B82W3) with a linear range of 2-20 ng/mL (QC tested).

产品背景:
FCGRT & B2M heterodimer protein (FcRn complex) consist of two subunits: p51 (equivalent to FCGRT), and p14 (equivalent to beta-2-microglobulin), and forms an MHC class I-like heterodimer. Fc fragment of IgG, receptor, transporter, alpha (FCGRT) binds to the Fc region of monomeric immunoglobulins gamma and mediates the uptake of IgG from milk. FCGRT possible role in transfer of immunoglobulin G from mother to fetus. Beta-2-microglobulin (B2M) is a component of the class I major histocompatibility complex (MHC) and involved in the presentation of peptide antigens to the immune system.

产品描述:
The subunit FCGRT carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™). The protein has a calculated MW of 34.5 kDa (FCGRT), 11.6 kDa (B2M) . The protein migrates as 37 kDa (FCGRT), 12 kDa (B2M) respectively on a SDS-PAGE gel under reducing (R) condition due to glycosylation.
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