Mouse NRP2 / Neuropilin 2 ELISA Kit (Sandwich ELISA) - LS-F10505Catalog Size Price LS-F10505-1 1 plate $665 USD Request Bulk Add to Wish List Add to Cart SpecificationsPublicationsReviewsImagesProduct DescriptionLS-F10505 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Mouse NRP2 / Neuropilin 2 in samples of Cell Culture Supernatants, Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of NRP2 / Neuropilin 2 as low as 10 picograms per milliliter.SpecificationsType
This kit is for the detection of natural and recombinant mouse Neuropilin-2. No significant cross-reactivity or interference between Neuropilin-2 and analogs was observed. Manual
Intended Sample Types
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates Format
Short term: 4°C; Long term: see manual. Quality Assurance
Due to their limited shelf life, LSBio ELISA kits are not typically stocked as finished goods. Upon receipt of an order each kit is assembled and tested to ensure that it meets specifications before shipping. Minor changes may occur to the Range, Sensitivity, and Precision. In the event of a significant change the order would be confirmed with the customer before shipping ELISA kit lot numbers reflect the date of final assembly and testing for each specific kit rather than a bulk manufactured lot. All kits are tested to confirm that they fall within their defined Inter- and Intra- assay coefficient of variation. Kit Components
User Manual
96-well Microplate
Detection Reagents
Wash Buffer
Substrate
Stop Solution
Adhesive Plate Sealers
Background
NRP2(Neuropilin-2), also called Npn2 or VEGF165R2, encodes a member of the neuropilin family of receptor proteins. The soluble NRP2 was secreted as a 62.5-kD protein following transfection in Chinese hamster ovary cells. The NRP2 gene is mapped to 2q33.3. The NRP2 gene contains 17 exons and spans about 112 kb. This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Mice with null mutations in genes encoding Sema3F, and its holoreceptor components Npn2 and plexin A3 (PLEXA3), exhibit increased dentate gyrus granule cell and cortical layer V pyramidal neuron spine number and size, and also aberrant spine distribution. Moreover, Sema3F promotes loss of spines and excitatory synapses in dissociated neurons in vitro, and in NRP2-null brain slices cortical layer V and dentate gyrus granule cells exhibit increased miniature excitatory postsynaptic current frequency. These disparate effects of secreted semaphorins are reflected in the restricted dendritic localization of NRP2 to apical dendrites and of Npn1 to all dendrites of cortical pyramidal neurons. Restrictions
For research use only. Guarantee
This elisa kit carries the LSBio Guarantee. About NRP2 / Neuropilin 2
O60462 NM_201266 NP_957718.1
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Mouse NRP2 / Neuropilin 2 ELISA Kit (Sandwich ELISA) - LS-F10505
