产品英文名称: Recombinant Human Myosin Light Chain 2
英文简称:MYL2
中文名称:重组人心室肌球蛋白轻链LC2
背景资料:MYL2 regulatory light chain is associated with cardiac myosin beta (or slow) heavy chain. Ca+ activates the phosphorylation of regulatory light chain that in turn activates contraction. Mutations in this MYL2 gene are related with mid-left ventricular chamber type hypertrophic cardiomyopathy. MYL2 is an essential protein that plays a role in the regulation of myosin ATPase activity in smooth muscle. MYL2 phosphorylation is regulated by ROCK and MLC kinase and is involved in platelet biogenesis by controlling proplatelet formation and fragmentation.
产品描述:MYL2 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 186 amino acids (1-166) and having a molecular mass of 20.9 kDa. MYL2 is fused to a 20 amino acid His Tag fused at N-terminus and purified by proprietary chromatographic techniques.
来源宿主:大肠杆菌中重组表达
序列:MGSSHHHHHH SSGLVPRGSH MAPKKAKKRA GGANSNVFSM FEQTQIQEFK EAFTIMDQNR DGFIDKNDLR DTFAALGRVN VKNEEIDEMI KEAPGPINFT VFLTMFGEKL KGADPEETIL NAFKVFDPEG KGVLKADYVR EMLTTQAERF SKEEVDQMFA AFPPDVTGNL DYKNLVHIIT HGEEKD.
溶解建议:Sterile filtered colorless solution. MYL2 solution containing 20mM Tris pH-8 pH-7.4, 20% glycerol, 5mM CaCl2.
保存建议:MYL2 Human Recombinant although stable at 4℃ for 1 week, should be stored desiccated below -18℃.Please prevent freeze thaw cycles.
其他简介: ProSpec是一家细胞因子蛋白及相关抗体生产和研发品Pai。ProSpec的生产和研发工厂位于以色列,专注于蛋白(重组及合成)生产研发,其独有的细菌和哺乳动物表达和蛋白折叠技术使其能在17年内成长为国际的科研级蛋白供应商。目前ProSpec可以提供细胞因子,生长因子,激素,信号蛋白,病毒抗原等近800种重组蛋白和100多种抗体,是世界上提供蛋白品种Z多的公司之一,领先的生产工艺和规模使其可以提供毫克到克级蛋白,价格优于同类公司。绝大部分产品是天然成熟型蛋白,而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液,ProSpec-Tany绝大部分产品没有添加保护剂或盐,这就对工艺提出了更高的要求。同时,ProSpec-Tany绝大部分产品为冻干粉,因此易于运输和保存。
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温馨提示:不可用于临床ZL。