CD314 (NKG2D)-PE/CD314 (NKG2D) antibodies, rat

品Pai:miltenyi，产品名称：CD314 (NKG2D)-PE, rat 200 tests
CD314 (NKG2D) antibodies, rat - Miltenyi Biotec
货号：130-106-927
Clone REA471 recognizes the rat CD314 antigen, a single-pass type II membrane homodimeric glycoprotein belonging to the C-type lectin-like receptor family, which is also known as NKG2-D type II integral membrane protein (NKG2D) or killer cell lectin-like receptor subfamily K member 1 (Klrk1). Rat CD314 is expressed in NK cells, and is strongly expressed in resting CD8⁺ and CD4⁺ T cells, but not by thymocytes or other hemopoietic cells. It functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. CD314 provides both, stimulatory and costimulatory innate immune responses on activated killer cells, leading to cytotoxic activity. It acts as a costimulatory receptor for T cell–receptor in CD8⁺ T cell–mediated adaptive immune responses by amplifying T cell–activation. Ligands of CD314 belong to various subfamilies of MHC class I–related glycoproteins.
Additional information: Clone REA471 displays negligible binding to Fc receptors.

Alternative namesKlrk1, Nkg2d, NKLLR, NKR-P2, NKR-P2, NKG2D

Clone and isotype

Clone	Isotype
REA471	recombinant human IgG1