FITC标记的DNA聚合酶κ/DNA pol κ抗体_详细资料

产品信息

货号： LM-13019R-FITC 保存条件： -20 °C 浓度： 1mg/ml 应用范围： Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200 形态：粉末、液体、冻干粉亚型： IGg 免疫原：详见说明书适应物种： Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, 宿主： Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, 标记物： FITC标记抗体名： Anti-DNA Polymerase Kappa/POLK/FITC 抗体英文名： Anti-DNA Polymerase Kappa/POLK/FITC 保质期： 1年抗原来源： Rabbit 克隆性：多克隆目录编号： LM-13019R-FITC 级别： 1 靶点：详见说明书数量：大量供应商：上海联迈生物工程有限公司规格： 100ul

FITC标记的DNA聚合酶κ/DNA pol κ抗体

英文名称 Anti-DNA Polymerase Kappa/POLK/FITC

中文名称 FITC标记的DNA聚合酶κ/DNA pol κ抗体

别    名 DNA polymerase kappa; DINB protein; Short=DINP; POLK_HUMAN.

规格价格 100ul/2980元购买        大包装/询价

说明书 100ul

研究领域细胞生物  表观遗传学

抗体来源 Rabbit

克隆类型 Polyclonal

交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,

产品应用 Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分子量 99kDa

性    状 Lyophilized or Liquid

浓    度 1mg/ml

免疫原 KLH conjugated synthetic peptide derived from human DNA Polymerase Kappa/POLK

亚    型 IgG

纯化方法 affinity purified by Protein A

储存液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

产品介绍 background:
DNA polymerase lambda (pol Kappa), also designated DNA polymerase Kappa or Pol Beta2, is a low-fidelity polymerase which plays a role in both spontaneous and DNA damage-induced mutagenesis. Encoded by the POLL gene, pol Kappa is a member of the DNA polymerase type-X family. Pol Kappa extends primer-terminal mispairs opposite nondamaged DNA templates, suggesting that it may assist in extending mismatched base pairs during normal DNA replication. In addition, pol Kappa may play a role in the mutagenic bypass of T-T dimers. Proliferating cell nuclear antigen (PCNA), a protein essential to DNA replication, interacts with pol Kappa and thus influences the ability of pol Kappa to synthesize DNA.

Function:
Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity.

Subunit:
Interacts with REV1 (By similarity). Interacts with PCNA.

Subcellular Location:
Nucleus. Accumulates at replication forks after DNA damage.

Tissue Specificity:
Detected at low levels in testis, spleen, prostate and ovary. Detected at very low levels in kidney, colon, brain, heart, liver, lung, placenta, pancreas and peripheral blood leukocytes.

Similarity:
Belongs to the DNA polymerase type-Y family.
Contains 1 umuC domain.

Database links:
UniProtKB/Swiss-Prot: Q9UBT6.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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FITC标记的DNA聚合酶κ/DNA pol κ抗体

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英文名称	Anti-DNA Polymerase Kappa/POLK/FITC
中文名称	FITC标记的DNA聚合酶κ/DNA pol κ抗体
别名	DNA polymerase kappa; DINB protein; Short=DINP; POLK_HUMAN.
规格价格	100ul/2980元购买大包装/询价
说明书	100ul
研究领域	细胞生物表观遗传学
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
产品应用	Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	99kDa
性状	Lyophilized or Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human DNA Polymerase Kappa/POLK
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍	background: DNA polymerase lambda (pol Kappa), also designated DNA polymerase Kappa or Pol Beta2, is a low-fidelity polymerase which plays a role in both spontaneous and DNA damage-induced mutagenesis. Encoded by the POLL gene, pol Kappa is a member of the DNA polymerase type-X family. Pol Kappa extends primer-terminal mispairs opposite nondamaged DNA templates, suggesting that it may assist in extending mismatched base pairs during normal DNA replication. In addition, pol Kappa may play a role in the mutagenic bypass of T-T dimers. Proliferating cell nuclear antigen (PCNA), a protein essential to DNA replication, interacts with pol Kappa and thus influences the ability of pol Kappa to synthesize DNA. Function: Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity. Subunit: Interacts with REV1 (By similarity). Interacts with PCNA. Subcellular Location: Nucleus. Accumulates at replication forks after DNA damage. Tissue Specificity: Detected at low levels in testis, spleen, prostate and ovary. Detected at very low levels in kidney, colon, brain, heart, liver, lung, placenta, pancreas and peripheral blood leukocytes. Similarity: Belongs to the DNA polymerase type-Y family. Contains 1 umuC domain. Database links: UniProtKB/Swiss-Prot: Q9UBT6.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.