Endoglin Antibody (Mouse Specific)

品Pai:CST，产品名称：Endoglin Antibody (Mouse Specific) #3290
英文名称：Endoglin Antibody (Mouse Specific)
Product name：Endoglin Antibody (Mouse Specific) #3290
Source：Rabbit
Sensitivity：Transfected Only
MW(kDa)：79, 81
Applications：WB ,
Purification： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro430 of mouse endoglin. Antibodies are purified by peptide affinity chromatography.
Background： Endoglin (ENG, CD105) is an auxiliary receptor for the TGF-β receptor complex, functioning in related signaling pathways (1,2). Endoglin is a transmembrane protein that exists as a disulfide-linked homodimer. It is mainly expressed in vascular and connective tissues and in endothelial and stromal cells. Upregulated endoglin expression has been reported during wound healing and tumor vascularization, and in inflammatory tissues and developing embryos (1-4). Mutations in endoglin have been found to be a causal factor of hereditary hemorrhagic telangiectasia (HHT), a disease characterized by malformation of vascular structure (5,6). The importance of this protein for normal and tumor vascular function makes it a good marker for endothelial cell proliferation as well as a potential therapeutic target in cancer (4-6).

Entrez-Gene Id

Swiss-Prot Acc.

Specificity / Sensitivity:

Endoglin Antibody (Mouse Specific) detects transfected levels of mouse endoglin protein.

Species Reactivity:

Mouse

Storage:

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.