中文名称:盐酸诺拉曲塞 英文名称:AG-337;Nolatrexed dihydrochloride CAS:152946-68-4 货号:T2940a 分子式:C14H14Cl2N4OS 分子量:357.26 分子活性描述:Nolatrexed Dihydrochloride is the dihydrochloride salt of nolatrexed, a water-soluble lipophilic quinazoline folate analog with antineoplastic activity. Nolatrexed occupies the folate binding site of thymidylate synthase, resulting in inhibition of thymidylate synthase activity and thymine nucleotide synthesis with subsequent inhibition of DNA replication, DNA damage, S-phase cell cycle arrest, and caspase-dependent apoptosis. This agent also exhibits radiosensitizing activity.