Recombinant Human Sox2-TAT_详细资料

产品信息 供应商：安诺伦（北京）生物科技有限公司规格： 1mg 靶点/蛋白质：MYNMMETEL KPPGPQQTS GGGGGNSTA AAAGGNQKN SPDRVKRPM NAFMVWSRG QRRKMAQEN PKMHNSEIS KRLGAEWKL LSETEKRPF IDEAKRLRA LHMKEHPDY KYRPRRKTK TLMKKDKYT LPGGLLAPG GNSMASGVG VGAGLGAGV NQRMDSYAH MNGWSNGSY SMMQDQLGY PQHPGLNAH GAAQMQPMH RYDVSALQY NSMTSSQTY MNGSPTYSM SYSQQGTPG MALGSMGSV VKSEASSSP PVVTSSSHS RAPCQAGDL RDMISMYLP GAEVPEPAA PSRLHMSQH YQSGPVPGT AINGTLPLS HMGGYGRKK RRQRRR 来源：E. Coli 官网链接：http://www.bio-gems.com/recombinant-proteins/other-proteins/recombinant-human-sox2-tat.html 商品关键词：Recombinant Human Sox2-TAT,110-03T-1mg,Biogems 简单描述：Sox2, also known as sex determining region Y (SRY)-box 2, belongs to a diverse family of structurally-related transcription factors whose primary structure contains a 79-residue DNA-binding domain, called high mobility group (HMG) box. It plays an essential role in maintaining the pluripotency of embryonic stem cells (ESC) and determination of cell fate. Microarray analysis showed that Sox2 regulates the expression of multiple genes involved in embryonic development including FGF-4, YES1 and ZFP206. Sox2 acts as a transcriptional activator after forming a ternary complex with Oct3/4 and a conserved non-coding DNA sequence (CNS1) located approximately 2 kb upstream of the RAX promoter. The introduction of Sox2, Oct4, Myc, and Klf4, into human dermal fibroblasts isolated from a skin biopsy of a healthy research fellow was sufficient to confer a pluripotent state upon the fibroblast genome. The reprogrammed cells thus obtained resemble ESC in morphology, gene expression, and in the capacity to form teratomas in immune-deficient mice. Sox2 and other transcription factors have been introduced into cells by DNA transfection, viral infection, or microinjection. Protein transduction using TAT fusion proteins represents an alternative methodology for introducing transcription factors and other nuclear proteins into primary as well as transformed cells. Recombinant human Sox2-TAT expressed in E. coli is a 36 kDa protein containing 330 amino-acid residues, including the 317 residues of full-length Sox2 and a 13-residue C-terminal TAT peptide (GGYGRKKRRQRRR). Purity: Above 95% as determined by SDS-PAGE Analysis. Biological Activity: Data Not Available. 官网链接: www.annoron.com 办公电话: 010-56256916 官方售后: 400-965-8633 企业QQ: 3198592576、3212874516 温馨提示：不可用于临床ZL。

您可能感兴趣的产品

Recombinant Human Sox2-TAT

产品信息

联系我们

关注我们