重组小鼠PCSK9(前蛋白转化酶枯草杆菌蛋白酶kexin-9) 重组蛋白

特别声明：本产品及我公司所售其他产品均为科研类试剂产品，严禁用于药物、YL及其他非科研用途。

北京百奥莱博专业生产销*(代"售")重组小鼠PCSK9(前蛋白转化酶枯草杆菌蛋白酶kexin-9) 重组蛋白，我公司供应的分子生物学试剂品类齐全，且具有优势价格，欢迎新老客户垂询订购。

名称：重组小鼠PCSK9(前蛋白转化酶枯草杆菌蛋白酶kexin-9) 重组蛋白
编号：JN0844
规格：10μg|50μg|500μg|1mg
英文名：Recombinant Mouse Proprotein Convertase Subtilisin/Kexin Type 9
品Pai：百奥莱博
产地：北京
本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Gln35-Gln155&Ser156-Gln692在C端含有His标签。

PCSK9质量控制：＞95%(还原性SDS-PAGE)

PCSK9制剂：液体

PCSK9保存：收到货后请置于-20℃，可保存6个月，避免反复冻融。

关于PCSK9：
Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER , the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis.PCSK9 also plays a role in neural development.

重组小鼠PCSK9(前蛋白转化酶枯草杆菌蛋白酶kexin-9) 重组蛋白极具性价比，此外，我公司正火爆促销以下产品：
SV0116 BclI限制性内切酶 BclI Restriction Endonuclease
BTN100867 SDS-PAGE浓缩胶配胶液 SDS-PAGE Stacking Gel Buffer
HR0177 植物膜蛋白提取试剂盒(2D电泳用) Plant membrane protein extraction kit (2D electrophoresis)
YT941 KSPYZ剂(SB-715992)(伊斯平斯) Ispinesib
YT083 通用型QL抗原修复液(10X) All-purpose Powerful Antigen Retrieval Solution
BTN120630 荧光素-12-dUTP溶液 Fluorescein-12-dUTP Solution
SV1517 α1-2,3 甘露糖苷酶
YT284 一氧化*(代"氮")清除剂(Hemoglobin) Nitric Oxide Scavenger
KFS363 胆碱酯酶测试盒(CHE)
SY0611 重组人表皮生长因子 Recombinant Human EGF
SV0801 Nt.AlwI切刻内切酶 Nt.AlwI切刻内切酶
WE0273 微量BCA蛋白定量试剂盒 Micro BCA Protein Assay Kit
KFS018 Oct-4免疫组化试剂盒(IHC)
SY0244 红色核酸染料(10000×)(同DuRed、GelRed) Red Nucleic Acid Gel Stain (10,000×in Water)
RFT092 2×Long Taq PCR MasterMix
BTN131008 弱RIPA裂解液 RIPA Lysis Buffer(Weak)
ALH339 平末端载体连接试剂盒（含多克隆位点）(T4连接酶技术) Zero background flat end fast connection kit(with mcs)
重组小鼠PCSK9(前蛋白转化酶枯草杆菌蛋白酶kexin-9) 重组蛋白关键词：重组PCSK9,重组小鼠前蛋白转化酶枯草杆菌蛋白酶kexin-9,JN0844,重组小鼠PCSK9,重组小鼠PCSK9蛋白


·重组人LAIR1(白细胞相关免疫球蛋白样受体1)
编号：JN1678
英文名称：Recombinant Human Leukocyte-Associated Immunoglobulin-Like Receptor 1
规格：10μg|50μg|500μg|1mg
本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Gln22-His163在C端含有His标签。

LAIR1质量控制：＞95%(还原性SDS-PAGE)

LAIR1制剂：冻干品

LAIR1保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

LAIR1复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于LAIR1：
Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) is a single-pass type I membrane protein. LAIR1 expressed on the majority of peripheral mononuclear cells, including natural killer (NK) cells, T-cells, B-cells, monocytes, and dendritic cells, highly in naive T-cells and B-cells. As an inhibitory receptor, LAIR1 plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. LAIR1 plays inhibitory role independently of SH2-containing phosphatases and modulates cytokine production in CD4+ T-cells. It down-regulates IL2 and IFNG production while inducing secretion of transforming growth factor beta, also down-regulates IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. LAIR1 inhibits the differentiation of peripheral blood precursors towards dendritic cells. It also restrains proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells.


重组小鼠PCSK9(前蛋白转化酶枯草杆菌蛋白酶kexin-9) 重组蛋白关键词：重组PCSK9,重组小鼠前蛋白转化酶枯草杆菌蛋白酶kexin-9,JN0844,重组小鼠PCSK9,重组小鼠PCSK9蛋白


·重组人神经调节蛋白-1β(NRG-1β)
编号：JN1311
英文名称：Recombinant Human Neuregulin-1 beta
规格：10μg|50μg|500μg|1mg
本品由我们的大肠杆菌表达系统制备而成，目的基因编码的Ser2-Lys246表达纯化得来。

NRG1质量控制：＞95%(还原性SDS-PAGE)

NRG1制剂：冻干品

NRG1保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

NRG1复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于NRG1：
Pro-neuregulin-1,Neuregulin-1 beta 1(NRG1) is asingle-pass type I membrane protein and belongs to the neuregulin family .It contains 1 EGF-like domain and 1 Ig-like C2-type (immunoglobulin-like) domain. Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. The protein concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development.

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