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产品名称：重组人IL-1RA
英文名称：Recombinant Human Interleukin-1 Receptor Antagonist
产品货号：GS4818
产品规格：20μg
分子量：Approximately 17.1kDa,a single non-glycosylated polypeptide chain containing 152 amino acids.
储存条件：冷冻（-20℃）
概述
Interleukin-1 receptor antagonist(IL-1RA)is a member of the IL-1 family.IL-1RA is secreted by various types of cells including immune cells,epithelial cells,and adipocytes,and is a natural inhibitor of the pro-inflammatory effect of IL-1β.This protein inhibits the activities of interleukin 1,alpha(IL-1α)and interleukin 1,beta(IL-1β),and modulates a variety of interleukin 1 related immune and inflammatory responses.IL-4 and IL-13 have been shown to amplify the stimulatory effect of IL1-beta on the production of soluble and intracellular forms of IL1-RA.The regulated expression of IL-1RA in various cell types has been shown to be influenced by cytokines.In synovial fibroblasts the synthesis of IL-1RA is markedly enhanced by IL-1,TNF-α,or PDGF.The protein shows 26%amino acid homology to IL-1β and 19%homology to IL-1α.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
| 外观 |
Sterile Filtered White lyophilized(freeze-dried)powder. |
| 纯度 |
＞96%by SDS-PAGE and HPLC analyses. |
| 来源 |
Escherichia coli. |
| 生物活性 |
Fully biologically active when compared to standard.The as determined by inhibiting IL-1α-dependent proliferation of murine D10S cells is less than 40ng/ml,corresponding to a specific activity of>2.5×104 IU/mg in the presence of 50pg/ml rHuIL-1α. |
| 成分 |
Lyophilized from a 0.2μmfiltered concentrated solution in PBS,pH 7.4. |
| 内毒素 |
Less than 1 EU/μg of rHuIL-1RA as determined by LAL method. |
| 复溶 |
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions. |
| 氨基酸序列 |
RPSGRKSSKM QAFRIWDVNQ KTFYLRNNQL VAGYLQGPNV NLEEKIDVVP IEPHALFLGI HGGKMCLSCV KSGDETRLQL EAVNITDLSE NRKQDKRFAF IRSDSGPTTS FESAACPGWF LCTAMEADQP VSLTNMPDEG VMVTKFYFQE DE |
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关注
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