Sp1多克隆抗体

Immunogen: Synthesized peptide derived from human Sp1 around the non-phosphorylation site of T739.

Synonym: SP1; TSFP1; Transcription factor Sp1

Reactivity: H,M,R

Clonality: Polyclonal

Calculated MW:81 kDa

Observed MW: 85 kDa

Source: Rabbit

Isotype: IgG

Application: WB,IHC,IF,ELISA

Purify: Affinity purification

Concentration: 1 mg/ml

Storage Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide..

Storage:  Store at -20℃. Avoid freeze / thaw cycles.

实验图片

Western Blot analysis of A549 cells using Sp1 Polyclonal Antibody

Blackground:Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression.

产品推荐

WB抗体：http://www.elabscience.cn/page/antibody/antibody-wb.html

IF抗体：http://www.elabscience.cn/page/antibody/antibody-if.html

IHC抗体：http://www.elabscience.cn/page/ihc/antibody-ihc.html

兔多克隆抗体定制：

http://www.elabscience.cn/page/antibody/rabbit-polyclonal-antibody-custom-service.html