Biotinylated Human CD3 epsilon

内毒素:
Less than 1.0 EU per μg by the LAL method.

纯度:
>95% as determined by reduced SDS-PAGE. 

活性:


产品背景:
CD3e molecule, epsilon also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. CD3E gene has also been linked to a susceptibility to type I diabetes in women. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2.

产品描述:
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 13.2 kDa. The protein migrates as 18-20 kDa on a SDS-PAGE gel under reducing (R) condition due to glycosylation.