MARCKSL1 antibody - C-terminal region | LBP83940 | Leading Biology

商品分类：多克隆抗体

来源：Rabbit

存储溶液：Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

参考文献：Blockx H.,et al.Submitted (FEB-1993) to the EMBL/GenBank/DDBJ databases.Bechtel S.,et al.BMC Genomics 8:399-399(2007).Gregory S.G.,et al.Nature 441:315-321(2006).Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.Olsen J.V.,et al.Cell 127:635-648(2006).

特异性：Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Dog

别名：MARCKS-related protein, MARCKS-like protein 1, Macrophage myristoylated alanine-rich C kinase substrate, Mac-MARCKS, MacMARCKS, MARCKSL1, MLP, MRP

简单描述：Rabbit Polyclonal MARCKSL1 antibody - C-terminal region. Validated for use in WB.

详情：FunctionControls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May also affect cancer cell migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems (By similarity).Cellular_LocationCytoplasm. Cell membrane. Note=Associates with the membrane via the insertion of the N-terminal N-myristoyl chain and the partial insertion of the effector domain. Association of the effector domain with membranes may be regulated by Ca(2+)/calmodulin (By similarity) In prostate cancers, detected in the cytoplasm and associated with apical or basal membranes (By similarity).

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