HUMAN-CTNND1_isform 2ABC(Y174) Antibody | LBP83536 | Leading Biology

商品分类：多克隆抗体

产品概述：Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). Associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.

靶点/蛋白：This antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 160-200 amino acids from human.

来源：Rabbit

存储溶液：Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

参考文献：Keirsebilck A.,et al.Genomics 50:129-146(1998).Nagase T.,et al.DNA Res. 4:141-150(1997).Ota T.,et al.Nat. Genet. 36:40-45(2004).Taylor T.D.,et al.Nature 440:497-500(2006).Kim L.,et al.Mol. Cell. Biol. 15:4553-4561(1995).

特异性：Human

别名：Catenin delta-1, Cadherin-associated Src substrate, CAS, p120 catenin, p120(ctn), p120(cas), CTNND1, KIAA0384

应用：WB~~1:1000

简单描述：Rabbit Polyclonal HUMAN-CTNND1_isform 2ABC(Y174) Antibody. Validated for use in WB, E.

详情：FunctionBinds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). Associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.Cellular_LocationCytoplasm. Nucleus. Cell membrane. Note=Interaction with GLIS2 promotes nuclear translocation (By similarity). Detected at cell-cell contacts. NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm Isoforms 4A and 1AB are excluded from the nucleus. Isoform 2A: Nucleus.Tissue_LocationExpressed in vascular endothelium. Melanocytes and melanoma cells primarily express the long isoform 1A, whereas keratinocytes express shorter isoforms, especially 3A. The shortest isoform 4A, is detected in normal keratinocytes and melanocytes, and generally lost from cells derived from squamous cell carcinomas or melanomas. The C-terminal alternatively spliced exon B is present in the p120ctn transcripts in the colon, intestine and prostate, but lost in several tumor tissues derived from these organs.

生物商城：http://www.annoron.com

办公电话：010-56256916

官方售后：400-965-8633

企业 QQ：3212874516、3198592576

地 址：北京大兴经济技术开发区(亦庄)同济中路7号兴盛国际A栋4层