Goat Anti-ILK (Restricted sale due to demands of patent holder) Antibody | LBP83072 | Leading Biology

商品分类：多克隆抗体

产品概述：Receptor-proximal protein kinase regulating integrin- mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.

来源：Goat

存储溶液：0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

参考文献：Hannigan G.E.,et al.Nature 379:91-96(1996).Janji B.,et al.Oncogene 19:3069-3077(2000).Tadic B.,et al.Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.Melchior C.,et al.Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.Ebert L.,et al.Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.

特异性：Human, Mouse

别名：Integrin-linked protein kinase, 2.7.11.1, 59 kDa serine/threonine-protein kinase, ILK-1, ILK-2, p59ILK, ILK, ILK1, ILK2

简单描述：Goat Polyclonal Goat Anti-ILK (Restricted sale due to demands of patent holder) Antibody. Validated for use in WB, E.

详情：FunctionReceptor-proximal protein kinase regulating integrin- mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.Cellular_LocationCell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium. Cytoplasm, myofibril, sarcomereTissue_LocationHighly expressed in heart followed by skeletal muscle, pancreas and kidney. Weakly expressed in placenta, lung and liver

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