Doublecortin / DCX (aa232-242) Antibody (internal region) | LBP77933 | Leading Biology

商品分类：多克隆抗体

产品概述：This antibody is expected to recognize all four reported isoforms (NP_000546.2; NP_835365.1; NP_835364.1; NP_001182482.1). Reported variants represent identical protein: NP_835364.1 and NP_835366.1.

来源：Goat

存储溶液：0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin

参考文献：MiR-128 up-regulation inhibits Reelin and DCX expression and reduces neuroblastoma cell motility and invasiveness. Evangelisti C, Florian MC, Massimi I, Dominici C, Giannini G, Galardi S, Bu?¨ MC, Massalini S, McDowell HP, Messi E, Gulino A, Farace MG, Ciafr?¨ SA, The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009 Dec 23 (12): 4276-87. PMID: 19713529

特异性：Mouse

别名：Neuronal migration protein doublecortin, Doublin, Lissencephalin-X, Lis-X, DCX, DBCN, LISX

简单描述：Goat Polyclonal Doublecortin / DCX (aa232-242) Antibody (internal region). Validated for use in WB, E.

详情：FunctionMicrotubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration.Cellular_LocationCytoplasm. Cell projection. Note=Localizes at neurite tips.Tissue_LocationHighly expressed in neuronal cells of fetal brain (in the majority of cells of the cortical plate, intermediate zone and ventricular zone), but not expressed in other fetal tissues. In the adult, highly expressed in the brain frontal lobe, but very low expression in other regions of brain, and not detected in heart, placenta, lung, liver, skeletal muscles, kidney and pancreas

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企业 QQ：3212874516、3198592576

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