DAG1 / Dystroglycan Antibody (Internal) | LBP77844 | Leading Biology

商品分类：多克隆抗体

产品概述：The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization. Beta-dystroglycan is a transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.

靶点/蛋白：Human DAG1 / Dystroglycan. Reported variants represent identical protein: NP_001159400.1, NP_004384.3

来源：Goat

参考文献：Ibraghimov-Beskrovnaya O.,et al.Hum. Mol. Genet. 2:1651-1657(1993).Ota T.,et al.Nat. Genet. 36:40-45(2004).Muzny D.M.,et al.Nature 440:1194-1198(2006).Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.Jung D.,et al.J. Biol. Chem. 270:27305-27310(1995).

特异性：Human, Mouse, Rat, Rabbit, Hamster, Monkey, Horse, Bovine, Dog

别名：Dystroglycan, Dystrophin-associated glycoprotein 1, Alpha-dystroglycan, Alpha-DG, Beta-dystroglycan, Beta-DG, DAG1

应用：ELISA (1:128000), IHC-P (5 μg/ml), WB (0.2-0.6 μg/ml)

简单描述：Goat Polyclonal DAG1 / Dystroglycan Antibody (Internal). Validated for use in WB, IHC-P, E.

详情：FunctionThe dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization. Beta-dystroglycan is a transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.Cellular_LocationAlpha-dystroglycan: Secreted, extracellular spaceTissue_LocationExpressed in a variety of fetal and adult tissues. In epidermal tissue, located to the basement membrane Also expressed in keratinocytes and fibroblasts

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