Anti-Bovine Neurofilament H 200kDa Antibody | LBP77248 | Leading Biology

商品分类：多克隆抗体

靶点/蛋白：Rabbit anti-Bovine Neurofilament H 200kDa antibody recognizes bovine intermediate 200kDa Neurofilament H (NFH), a 1026 amino acid ~200kDa protein involved in the maintenence of neuronal integrity.Neurofilaments are a major component of the cellular cytoskeleton, acting as the most abundant support for the axon cytoplasm. They exist as three neurofilament proteins: 68/70kDa (NFL) 160kDa (NFM) and 200kDa (NFH), which are expressed in both the central and peripheral nervous systems. Although typically expressed by neurons, neurofilaments are also expressed by neuroblastomas, neuromas, gangliogliomas, ganglioneuromas, and ganglioneuroblastomas, as well as paragangliomas, carcinoids, skin neuroendocrine carcinomas, and oat cell carcinomas of the lung (Lehtoet al.1983).Defects in NFH are responsible for susceptibility to the neurodegenerative disorder amyotrophic lateral sclerosis (ALS) which affects upper and lower motor neurons, and results in fatal paralysis (Mendonçaet al.2005).

来源：Rabbit

参考文献：1. Kaneko, S. et al. (2006) Protecting axonal degeneration by increasing nicotinamide adenine dinucleotide levels in experimental autoimmune encephalomyelitis models.J Neurosci. 26: 9794-804. 2. Li, Y. et al. (2008) Transplanted olfactory ensheathing cells incorporated into the optic nerve head ensheathe retinal ganglion cell axons: possible relevance to glaucoma.Neurosci Lett. 440: 251-4. 3. Ignatov, A. et al. (2003) Role of the G-protein-coupled receptor GPR12 as high-affinity receptor for sphingosylphosphorylcholine and its expression and function in brain development.J Neurosci. 23: 907-14. 4. Leypoldt, F. et al. (2002) Neuronal differentiation of cultured human NTERA-2cl.D1 cells leads to increased expression of synapsins.Neurosci Lett. 2002 May 10;324(1):37-40. 5. Savolainen, H. et al. (2009) Cortical demyelination in PML and MS: similarities and differences.Neurology. 72: 861. 6. Zhang, Z. et al. (2011) The role of single cell derived vascular resident endothelial progenitor cells in the enhancement of vascularization in scaffold-based skin regeneration.Biomaterials. 32: 4109-17. 1. Liu, Q. et al. (2004) Neurofilament proteins in neurodegenerative diseases.Cell. Mol. Life Sci.61: 3057-3075.

特异性：Bovine

别名：Neurofilament heavy polypeptide, NF-H, 200 kDa neurofilament protein, Neurofilament triplet H protein, Nefh, Kiaa0845, Nfh

简单描述：Rabbit Polyclonal Anti-Bovine Neurofilament H 200kDa Antibody . Validated for use in WB, IHC-P.

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