AOX1 / Aldehyde Oxidase Antibody (aa521-570) | LBP71849 | Leading Biology

商品分类：多克隆抗体

产品概述：Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide and N- methylphthalazinium, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. Also may catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. May play a role in adipogenesis.

靶点/蛋白：AOX1 Antibody detects endogenous levels of total AOX1 protein.

来源：Rabbit

参考文献：Wright R.M.,et al.Proc. Natl. Acad. Sci. U.S.A. 90:10690-10694(1993).Wright R.M.,et al.Redox Rep. 3:135-144(1997).Ichida K.,et al.Biochem. Biophys. Res. Commun. 282:1194-1200(2001).Hillier L.W.,et al.Nature 434:724-731(2005).Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

特异性：Human, Rat

别名：AOX1, AO, Aldehyde oxidase 1, AOH1, Aldehyde oxidase

应用：ELISA (1:40000), IHC-P (5 μg/ml), WB (1:500 - 1:1000),

简单描述：Rabbit Polyclonal AOX1 / Aldehyde Oxidase Antibody (aa521-570). Validated for use in WB, IHC-P, E.

详情：FunctionOxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide and N- methylphthalazinium, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. Also may catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. May play a role in adipogenesis.Cellular_LocationCytoplasmTissue_LocationAbundant in liver, expressed in adipose tissue and at lower levels in lung, skeletal muscle, pancreas. In contrast to mice, no significant gender difference in AOX1 expression level (at protein level).

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企业 QQ：3212874516、3198592576

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