AXIN1 / Axin-1 Antibody (C-Terminus) | LBP65881 | Leading Biology

商品分类：多克隆抗体

产品概述：Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt- independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development.

靶点/蛋白：Human AXIN

来源：Rabbit

参考文献：Zeng L.,et al.Cell 90:181-192(1997).Daniels R.J.,et al.Hum. Mol. Genet. 10:339-352(2001).Martin J.,et al.Nature 432:988-994(2004).Hsu W.,et al.J. Biol. Chem. 274:3439-3445(1999).Satoh S.,et al.Nat. Genet. 24:245-250(2000).

特异性：Human

别名：AXIN1, Axis inhibitor 1, AXIN, Axin 1, Axis inhibition protein 1, Fused, mouse, homolog of, HAxin, PPP1R49, Axin-1

应用：IHC-P (10 μg/ml), WB (1:500 - 1:3000),

简单描述：Rabbit Polyclonal AXIN1 / Axin-1 Antibody (C-Terminus). Validated for use in WB, IHC-P.

详情：FunctionComponent of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt- independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development.Cellular_LocationCytoplasm. Nucleus. Membrane. Cell membrane. Note=MACF1 is required for its translocation to cell membrane (By similarity). On UV irradiation, translocates to the nucleus and colocalizes with DAAXTissue_LocationUbiquitously expressed.

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