PAEL Receptor / GPR37 Antibody (N-Terminus) | LBP84352 | Leading Biology

商品分类：多克隆抗体

产品概述：Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade.

靶点/蛋白：Human GPR37. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

来源：Rabbit

参考文献：Marazziti D.,et al.Genomics 45:68-77(1997).Donohue P.J.,et al.Brain Res. Mol. Brain Res. 54:152-160(1998).Zeng Z.,et al.Biochem. Biophys. Res. Commun. 233:559-567(1997).Imai Y.,et al.Cell 105:891-902(2001).Hillier L.W.,et al.Nature 424:157-164(2003).

特异性：Human

别名：Prosaposin receptor GPR37, Endothelin B receptor-like protein 1, ETBR-LP-1, G-protein coupled receptor 37, Parkin-associated endothelin receptor-like receptor, PAELR, GPR37

应用：IHC-P (20 μg/ml)

简单描述：Rabbit Polyclonal PAEL Receptor / GPR37 Antibody (N-Terminus). Validated for use in IHC-P.

详情：FunctionReceptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade.Cellular_LocationCell membrane; Multi-pass membrane protein Endoplasmic reticulum membrane; Multi-pass membrane proteinTissue_LocationExpressed in brain and spinal cord, and at lower levels in testis, placenta and liver, but no detectable expression observed in any other tissue. When overexpressed in cells, tends to become insoluble and unfolded. Accumulation of the unfolded protein may lead to dopaminergic neuronal death in juvenile Parkinson disease (PDJ).

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