Cellular Apoptosis Susceptibility Antibody (C-term) | LBP81420 | Leading Biology

商品分类：多克隆抗体

产品概述：Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. CSE1L binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, CSE1L may play a role both in apoptosis and in cell proliferation.

靶点/蛋白：This Cellular Apoptosis Susceptibility antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 55-84 amino acids from the N-terminal region of human Cellular Apoptosis Susceptibility.

来源：Rabbit

存储溶液：Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

参考文献：Goldberg, G.S., et al., J. Biol. Chem. 278(47):46533-46540 (2003).Behrens, P., et al., Apoptosis 8(1):39-44 (2003).Jiang, M.C., et al., Biochem. Biophys. Res. Commun. 294(4):900-905 (2002).Wellmann, A., et al., Int. J. Mol. Med. 7(5):489-494 (2001).Brinkmann, U., et al., Genomics 58(1):41-49 (1999).

特异性：Human, Mouse

别名：Exportin-2, Exp2, Cellular apoptosis susceptibility protein, Chromosome segregation 1-like protein, Importin-alpha re-exporter, CSE1L, CAS, XPO2

应用：IHC-P~~1:100IF~~1:100WB~~1:1000

简单描述：Rabbit Polyclonal Cellular Apoptosis Susceptibility Antibody (C-term). Validated for use in WB, IHC-P, IF, E.

详情：FunctionExport receptor for importin-alpha. Mediates importin- alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.Cellular_LocationCytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasmTissue_LocationHighly expressed in proliferating cells.

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企业 QQ：3212874516、3198592576

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