SFN / Stratifin / 14-3-3 Sigma Antibody (N-Terminus) | LBP80378 | Leading Biology

商品分类：多克隆抗体

产品概述：Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.

靶点/蛋白：Recognizes 14-3-3 sigma in all mammals. It is a member of the 14-3-3 family which consists of 30 kD proteins that are involved in multiple protein kinase signalling pathways, regulation of cell cycle progression, cytoskeletal structure, transcription ...

来源：Rabbit

参考文献：Prasad G.L.,et al.Cell Growth Differ. 3:507-513(1992).Leffers H.,et al.J. Mol. Biol. 231:982-998(1993).Hermeking H.,et al.Mol. Cell 1:3-11(1997).Halleck A.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.Gregory S.G.,et al.Nature 441:315-321(2006).

特异性：Human, Mouse, Rat, Rabbit, Chicken, Sheep, Bovine

别名：14-3-3 protein sigma, Epithelial cell marker protein 1, Stratifin, SFN, HME1

应用：IHC-P (1:250)

简单描述：Rabbit Polyclonal SFN / Stratifin / 14-3-3 Sigma Antibody (N-Terminus). Validated for use in WB, IHC-P.

详情：FunctionAdapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.Cellular_LocationCytoplasm. Nucleus. Secreted. Note=May be secreted by a non-classical secretory pathwayTissue_LocationPresent mainly in tissues enriched in stratified squamous keratinizing epithelium

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