M1 Muscarinic Receptor (443-458) Antibody | LBP79128 | Leading Biology

商品分类：多克隆抗体

产品概述：The action of the neurotransmitter acetylcholine is mediated through two types of receptors, the ionotrophic nicotinic receptors and the metabotrophic muscarinic receptors. The muscarinic receptors belong to the superfamily of 7-TM G-protein coupled receptors. Five subtypes of muscarinic receptors have been cloned and named m1-m51,2.The muscarinic receptors are widely distributed throughout the body, but are predominantly expressed within the parasympathetic nervous system and exert both excitatory and inhibitory control over central and peripheral tissues1,2.Muscarinic receptors participate in a number of physiological functions such as regulation of heart rate, muscle contraction, cognition, sensory processing and motor control1. They also participate in learning and memory processing3,4. The m1 receptors are the most abundant muscarinic subtype in the cortex and striatum. m1 receptors are also localized in the myenteric plexus where they function as autoreceptors to enhance the release of Ach from the nerves5,6.The m1, m3 and m5 receptors, which are coupled to Gq/11 proteins, can protect cells from apoptosis induced by DNA damage. The signaling mechanism that mediates this anti-apoptotic response is still poorly understood. However, it was recently reported that a poly-basic motif in the C-terminus tail of the m1, m3 and m5 receptors is an essential element for the anti-apoptotic response of those receptors7.Abgent is pleased to offer a highly specific antibody directed against an epitope human m1 receptor. Anti-M1 Muscarinic Receptor (443-458) antibody (#AG1215) can be used in western blot analysis and immunohistochemistry applications. It has been designed to recognize m1 from mouse, ratand human samples.

靶点/蛋白：Peptide (C)RKIPKRPGSVHRTPSR, corresponding to amino acid residues 443-458 of human M1 Muscarinic Receptor (Accession P11229). Intracellular, C-terminus.

来源：Rabbit

存储溶液：Affinity purified antibody, lyophilized powder

参考文献：References1. Felder, C.C. et al. (2000) J. Med. Chem. 43, 4333.2. Forsythe, S.M. et al. (2002) Am. J. Respir. Cell. Mol. Biol. 26, 298.3. Ferreira, A.R. et al. (2003) Pharmacol. Biochem. Behav. 74, 411.4. Van der Zee, E.A. et al. (1999) Prog. Neurol. 58, 409.5. Levey, A.I. et al. (1991) J. Neurosci. 11, 3218.6. Wang, J. et al. (2000) Am. J. Physiol. 279, G1059.7. Budd, D.C. et al. (2003) J. Biol. Chem. 278, 19565.

特异性：Human, Mouse, Rat

别名：Muscarinic acetylcholine receptor M1, CHRM1

应用：WB~~1:200-1:2000IHC~~1:100

简单描述：Rabbit Polyclonal M1 Muscarinic Receptor (443-458) Antibody. Validated for use in WB.

生物商城：http://www.annoron.com

办公电话：010-56256916

官方售后：400-965-8633

企业 QQ：3212874516、3198592576

地 址：北京大兴经济技术开发区(亦庄)同济中路7号兴盛国际A栋4层