Human p75NTR(extracellular) Antibody | LBP78788 | Leading Biology

商品分类：多克隆抗体

产品概述：The p75NTR receptor is a member of the TNF receptor superfamily. p75NTR, like all the superfamily members is a type I transmembrane protein with tandem cysteine-rich domains in the extracellular portion and a intracellular death domain. p75NTR binds its ligands as a homodimer but can also form heterodimers with other receptors such as TrkA, TrkB, TrkC, Nogo receptor and sortilin. The precise multimeric receptor complex formed between p75NTR and the other receptors will determine the ligand being recognized (see below) and the biological response to its binding.As it name implies, p75NTR binds all the neurotrophins (NGF, BDNF, NT-3 and NT-4) with similar nM affinities. Co-expression of p75NTR with the Trk receptors enhances the ability to bind and respond to the specific neurotrophin and induces cell survival. On the other hand, it has recently been demonstrated that p75NTR binds with high affinity to the unprocessed form of NGF (proNGF) probably as a complex with sortilin and this leads to cell death by apoptosis. Finally, a multimeric complex of p75NTR and Nogo receptor binds myelin proteins such as Nogo-66, MAG and OmgP resulting in inhibition of axonal growth.Abgent has now developed a new antibody specific for the p75NTR (#AG1417). The antibody was raised against a highly conserved epitope located in the stalk domain of the human p75NTR extracellular region. The chosen epitope makes this antibody highly suited for several applications including indirect flow cytometry, immunocytochemistry, immunohistochemistry and western blot. The antibody works equally well in mouse and rat samples.

靶点/蛋白：Peptide CEEIPGRWITRSTPPE, corresponding to amino acid residues 188-203 of human p75NTR (SwissProt accession P08138). Extracellular, stalk domain.

来源：Rabbit

存储溶液：Affinity purified antibody, lyophilized powder

参考文献：References1. Hempstead, B.L. (2002) Curr. Opin. Neurobiol. 12, 260.2. Chao, M.V. (2003) Nat. Rev. Neurosci. 4, 299.3. Barker, P.A. (2004) Neuron 42, 529.

特异性：Human, Mouse, Rat

别名：Tumor necrosis factor receptor superfamily member 16, Gp80-LNGFR, Low affinity neurotrophin receptor p75NTR, Low-affinity nerve growth factor receptor, NGF receptor, p75 ICD, CD271, NGFR, TNFRSF16

应用：WB~~1:200-1:2000

简单描述：Rabbit Polyclonal Human p75NTR(extracellular) Antibody. Validated for use in WB, IP, LCI.

生物商城：http://www.annoron.com

办公电话：010-56256916

官方售后：400-965-8633

企业 QQ：3212874516、3198592576

地 址：北京大兴经济技术开发区(亦庄)同济中路7号兴盛国际A栋4层