PPARG / PPAR Gamma Antibody (Internal) | LBP74989 | Leading Biology

商品分类：多克隆抗体

产品概述：Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (By similarity).

靶点/蛋白：Amino acids 255 -268 of human PPAR gamma isoform 1.

来源：Rabbit

参考文献：Mukherjee R.,et al.J. Biol. Chem. 272:8071-8076(1997).Elbrecht A.,et al.Biochem. Biophys. Res. Commun. 224:431-437(1996).Yanase T.,et al.Biochem. Biophys. Res. Commun. 233:320-324(1997).Greene M.E.,et al.Gene Expr. 4:281-299(1995).Greene M.E.,et al.Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.

特异性：Human, Mouse, Rat, Rabbit, Hamster, Squirrel, Guinea Pig, Dog

别名：Peroxisome proliferator-activated receptor gamma, PPAR-gamma, Nuclear receptor subfamily 1 group C member 3, PPARG, NR1C3

应用：ELISA (1:8000-1:32000), IHC-P (5 μg/ml),

简单描述：Rabbit Polyclonal PPARG / PPAR Gamma Antibody (Internal). Validated for use in WB, IHC-P, E.

详情：FunctionNuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (By similarity).Cellular_LocationNucleus. Cytoplasm. Note=Redistributed from the nucleus to the cytosol through a MAP2K1/MEK1-dependent manner CCRN4L/NOC enhances its nuclear translocationTissue_LocationHighest expression in adipose tissue. Lower in skeletal muscle, spleen, heart and liver. Also detectable in placenta, lung and ovary.

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