PLN / Phospholamban Antibody (N-Terminus) | LBP74905 | Leading Biology

商品分类：多克隆抗体

产品概述：Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation.

靶点/蛋白：Human PLN / Phospholamban.

来源：Goat

参考文献：Fujii J.,et al.J. Biol. Chem. 266:11669-11675(1991).Salvatore C.A.,et al.Submitted (MAR-1991) to the EMBL/GenBank/DDBJ databases.McTiernan C.F.,et al.J. Mol. Cell. Cardiol. 31:679-692(1999).Minamisawa S.,et al.Biochem. Biophys. Res. Commun. 304:1-4(2003).Kaliman P.,et al.J. Biol. Chem. 280:8016-8021(2005).

特异性：Human, Mouse, Rat, Rabbit, Monkey, Pig, Horse, Bovine, Dog

别名：Cardiac phospholamban, PLB, PLN, PLB

应用：ELISA (1:8000), IHC-P (3.75 μg/ml), WB (0.01-0.03 μg/ml)

简单描述：Goat Polyclonal PLN / Phospholamban Antibody (N-Terminus). Validated for use in WB, IHC-P, E.

详情：FunctionReversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation.Cellular_LocationSarcoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single- pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane proteinTissue_LocationHeart muscle (at protein level).

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