CD71 / Transferrin Receptor Antibody (aa15-64) | LBP72294 | Leading Biology

商品分类：多克隆抗体

产品概述：Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.

靶点/蛋白：CD71/TfR (Ab-24) Antibody detects endogenous levels of total CD71/TfR protein.

来源：Rabbit

参考文献：Schneider C.,et al.Nature 311:675-678(1984).McClelland A.,et al.Cell 39:267-274(1984).Evans P.,et al.Gene 199:123-131(1997).Wheeler D.L.,et al.Thesis (1999), University of Iowa, United States.Totoki Y.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.

特异性：Human, Mouse

别名：Transferrin receptor protein 1, TR, TfR, TfR1, Trfr, T9, p90, CD71, Transferrin receptor protein 1, serum form, sTfR, TFRC

应用：ELISA (1:10000), IHC-P (1:50-1:100), WB (1:500-1:1000)

简单描述：Rabbit Polyclonal CD71 / Transferrin Receptor Antibody (aa15-64). Validated for use in WB, IHC-P, E.

详情：FunctionCellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.Cellular_LocationCell membrane; Single-pass type II membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV

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