TLR9 Antibody (C-Terminus) | LBP70778 | Leading Biology

商品分类：多克隆抗体

产品概述：Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Controls lymphocyte response to Helicobacter infection.

靶点/蛋白：peptide corresponding to 16 amino acids near the carboxy terminus of human TLR9

来源：Rabbit

参考文献：Du X.,et al.Eur. Cytokine Netw. 11:362-371(2000).Chuang T.-H.,et al.Eur. Cytokine Netw. 11:372-378(2000).Hemmi H.,et al.Nature 408:740-745(2000).Liu Z.,et al.Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.Nakajima T.,et al.Immunogenetics 60:727-735(2008).

特异性：Human, Mouse

别名：TLR9, CD289, CD289 antigen, Scri2a, Toll-like receptor 9

应用：IF (10 μg/ml), IHC-P (10 μg/ml), WB (1 - 2 μg/ml),

简单描述：Rabbit Polyclonal TLR9 Antibody (C-Terminus). Validated for use in WB, IHC-P, IF.

详情：FunctionKey component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Controls lymphocyte response to Helicobacter infection.Cellular_LocationEndoplasmic reticulum membrane; Single-pass type I membrane protein Endosome. Lysosome. Cytoplasmic vesicle, phagosome. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist.Tissue_LocationHighly expressed in spleen, lymph node, tonsil and peripheral blood leukocytes, especially in plasmacytoid pre- dendritic cells. Levels are much lower in monocytes and CD11c+ immature dendritic cells. Also detected in lung and liver

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