Goat Anti-SH2D1A/SLAM associated protein Antibody | LBP64836 | Leading Biology

商品分类：多克隆抗体

产品概述：This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene.

来源：Goat

存储溶液：0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin

参考文献：Customised molecular diagnosis of primary immune deficiency disorders in New Zealand: an efficient strategy for a small developed country. Ameratunga R, et al. N Z Med J, 2009 Oct 9. PMID 19859091.Restimulation-induced apoptosis of T cells is impaired in patients with X-linked lymphoproliferative disease caused by SAP deficiency. Snow AL, et al. J Clin Invest, 2009 Oct. PMID 19759517.The proapoptotic function of SAP provides a clue to the clinical picture of X-linked lymphoproliferative disease. Nagy N, et al. Proc Natl Acad Sci U S A, 2009 Jul 21. PMID 19570996.SAP binds to CD22 and regulates B cell inhibitory signaling and calcium flux. Ostrakhovitch EA, et al. Cell Signal, 2009 Apr. PMID 19150402.SLAM receptors and SAP influence lymphocyte interactions, development and function. Schwartzberg PL, et al. Nat Rev Immunol, 2009 Jan. PMID 19079134.

特异性：Human

别名：SH2 domain-containing protein 1A, Duncan disease SH2-protein, Signaling lymphocytic activation molecule-associated protein, SLAM-associated protein, T-cell signal transduction molecule SAP, SH2D1A, DSHP, SAP

简单描述：Goat Polyclonal Goat Anti-SH2D1A/SLAM associated protein Antibody. Validated for use in WB, IP, E.

详情：FunctionInhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the SLAM cytoplasmic region. Mediates interaction between FYN and SLAMF1. May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3.Cellular_LocationCytoplasm.Tissue_LocationExpressed at a high level in thymus and lung, with a lower level of expression in spleen and liver. Expressed in peripheral blood leukocytes, including T-lymphocytes. Tends to be expressed at lower levels in peripheral blood leukocytes in patients with rheumatoid arthritis.

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