fibrinogen beta chain Antibody (internal region) | LBP64748 | Leading Biology

商品分类：多克隆抗体

产品概述：This antibody is expected to recognize both reported isoforms (NP_005132.2; NP_001171670.1).

来源：Goat

存储溶液：0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin

参考文献：Fibrinogen beta-chain tyrosine nitration is a prothrombotic risk factor. Parastatidis I, Thomson L, Burke A, Chernysh I, Nagaswami C, Visser J, Stamer S, Liebler DC, Koliakos G, Heijnen HF, Fitzgerald GA, Weisel JW, Ischiropoulos H. The Journal of biological chemistry 2008 Dec 283 (49): 33846-53. PMID: 18818200

特异性：Human

别名：Fibrinogen beta chain, Fibrinopeptide B, Fibrinogen beta chain, FGB

简单描述：Goat Polyclonal fibrinogen beta chain Antibody (internal region). Validated for use in WB, E.

详情：FunctionCleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.Cellular_LocationSecreted.

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