SYT1 / Synaptotagmin Antibody (Internal) | LBP63535 | Leading Biology

商品分类：多克隆抗体

产品概述：May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.

靶点/蛋白：Human SYT1 / Synaptotagmin. Reported isoforms NP_005630.1, NP_001129277.1 and NP_001129278.1 represent identical protein.

来源：Goat

参考文献：Perin M.S.,et al.J. Biol. Chem. 266:615-622(1991).Ota T.,et al.Nat. Genet. 36:40-45(2004).Bechtel S.,et al.BMC Genomics 8:399-399(2007).Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.Han C.,et al.J. Immunol. 182:2986-2996(2009).

特异性：Human, Mouse, Rat, Rabbit, Zebrafish, Hamster, Monkey, Pig, Chicken, Horse, Bovine, Dog

别名：Synaptotagmin-1, Synaptotagmin I, SytI, p65, SYT1, SVP65, SYT

应用：ELISA (1:2000), IHC-P (3.75 μg/ml), WB (0.3-1 μg/ml)

简单描述：Goat Polyclonal SYT1 / Synaptotagmin Antibody (Internal). Validated for use in WB, IHC-P, E.

详情：FunctionMay have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.Cellular_LocationCytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single-pass membrane protein. Cytoplasm. Note=Synaptic vesicles and chromaffin granules

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