LF / LTF / Lactoferrin Antibody (Internal) | LBP62104 | Leading Biology

商品分类：多克隆抗体

产品概述：Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. Lactoferricin binds to the bacterial surface and is crucial for the bactericidal functions. Has some antiviral activity against papillomavirus infection. N-terminal region shows strong antifungal activity against C.albicans. Contains two BBXB heparin-binding consensus sequences that appear to form the predominate functional GAG-binding site. Lactoferroxins A, B and C have opioid antagonist activity. Lactoferroxin A shows preference for mu-receptors, while lactoferroxin B and C have somewhat higher degrees of preference for kappa-receptors than for mu-receptors. Isoform DeltaLf: transcription factor with antiproliferative properties and ability to induce cell cycle arrest. Binds to the DeltaLf response element found in the SKP1, BAX, DCPS, and SELH promoters.

靶点/蛋白：Human LTF / Lactoferrin.

来源：Goat

参考文献：Rey M.W.,et al.Nucleic Acids Res. 18:5288-5288(1990).Cho Y.Y.,et al.Thesis (1994), Genetic Engineering Research Institute, South Korea.Siebert P.D.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:2198-2203(1997).Cheng H.,et al.Sheng Wu Gong Cheng Xue Bao 17:385-387(2001).Kumar J.,et al.Indian J. Biochem. Biophys. 40:14-21(2003).

特异性：Human

别名：Lactotransferrin, Lactoferrin, 3.4.21.-, Growth-inhibiting protein 12, Talalactoferrin, Lactoferricin-H, Lfcin-H, Kaliocin-1, Lactoferroxin-A, Lactoferroxin-B, Lactoferroxin-C, LTF, GIG12, LF

应用：ELISA (1:32000), IHC-P (2 μg/ml), WB (0.05-0.2 μg/ml)

简单描述：Goat Polyclonal LF / LTF / Lactoferrin Antibody (Internal). Validated for use in WB, IHC-P, E.

详情：FunctionTransferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. Lactoferricin binds to the bacterial surface and is crucial for the bactericidal functions. Has some antiviral activity against papillomavirus infection. N-terminal region shows strong antifungal activity against C.albicans. Contains two BBXB heparin-binding consensus sequences that appear to form the predominate functional GAG-binding site. Lactoferroxins A, B and C have opioid antagonist activity. Lactoferroxin A shows preference for mu-receptors, while lactoferroxin B and C have somewhat higher degrees of preference for kappa-receptors than for mu-receptors. Isoform DeltaLf: transcription factor with antiproliferative properties and ability to induce cell cycle arrest. Binds to the DeltaLf response element found in the SKP1, BAX, DCPS, and SELH promoters.Cellular_LocationIsoform 1: Secreted. Cytoplasmic granule. Note=Secreted into most exocrine fluids by various endothelial cells. Stored in the secondary granules of neutrophilsTissue_LocationHigh levels are found in saliva and tears, intermediate levels in serum and plasma, and low levels in urine In kidney, detected in the distal collecting tubules in the medulla but not in the cortical region or in blood vessels Detected in peripheral blood neutrophils (at protein level) Isoform 1 and isoform DeltaLf are expressed in breast, prostate, spleen, pancreas, kidney, small intestine, lung, skeletal muscle, uterus, thymus and fetal liver. Isoform 1 is expressed in brain, testis and peripheral blood leukocytes; isoform DeltaLf is barely detectable in these tissues. Isoform DeltaLf is expressed in placenta, liver and ovary; isoform 1 is barely detectable in these tissues. In kidney, isoform 1 is expressed at high levels in the collecting tubules of the medulla but at very low levels in the cortex.

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