CDH1 / E Cadherin Antibody (aa1-50) | LBP60855 | Leading Biology

商品分类：多克隆抗体

产品概述：Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.

靶点/蛋白：E-cadherin Antibody detects endogenous levels of total E-cadherin protein.

来源：Rabbit

参考文献：Bussemakers M.J.G.,et al.Mol. Biol. Rep. 17:123-128(1993).Oda T.,et al.Proc. Natl. Acad. Sci. U.S.A. 91:1858-1862(1994).Rimm D.L.,et al.Biochem. Biophys. Res. Commun. 200:1754-1761(1994).Ito K.,et al.Oncogene 18:7080-7090(1999).Shibamoto S.,et al.Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.

特异性：Human

别名：Cadherin-1, CAM 120/80, Epithelial cadherin, E-cadherin, Uvomorulin, CD324, E-Cad/CTF1, E-Cad/CTF2, E-Cad/CTF3, CDH1, CDHE, UVO

应用：ELISA (1:40000), IF (1:100-1:500), IHC-P (5 μg/ml), WB (1:500-1:1000) ,

简单描述：Rabbit Polyclonal CDH1 / E Cadherin Antibody (aa1-50). Validated for use in WB, IHC-P, IF, E.

详情：FunctionCadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.Cellular_LocationCell junction. Cell membrane; Single-pass type I membrane protein. Endosome. Golgi apparatus, trans-Golgi network. Note=Colocalizes with DLGAP5 at sites of cell-cell contact in intestinal epithelial cells. Anchored to actin microfilaments through association with alpha-, beta- and gamma- catenin. Sequential proteolysis induced by apoptosis or calcium influx, results in translocation from sites of cell-cell contact to the cytoplasm. Colocalizes with RAB11A endosomes during its transport from the Golgi apparatus to the plasma membraneTissue_LocationNon-neural epithelial tissues.

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