CD8A (Cytotoxic- & Suppressor T-Cell Marker) Antibody - Without BSA and Azide | LBP60176 | Leading Biology

商品分类：多克隆抗体

产品概述：CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 β chain (CD8 α/β) or as a homodimer (CD8 α/α). A majority of thymocytes and a subpopulation of mature T cells and NK cell express CD8a. CD8 binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells. For mature T-cells, CD4 and CD8 are mutually exclusive, so anti-CD8, generally used in conjunction with anti-CD4. It is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral T-cell lymphomas are CD4+/CD8-. Anaplastic large cell lymphoma is usually CD4+ and CD8-, and in T-lymphoblastic lymphoma/leukemia, CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen.

来源：Rabbit

存储溶液：200?g/ml of antibody purified from rabbit anti-serum by Protein A chromatography. Supplied in 10mM PBS, pH 7.4 with 0.05% BSA and 0.05% sodium azide. Contact us if you require this antibody in a different format.

参考文献：Mason DY, et. al. Journal of Clinical Pathology, 1992, 45(12):1084-8

特异性：Human

别名：T-cell surface glycoprotein CD8 alpha chain, T-lymphocyte differentiation antigen T8/Leu-2, CD8a, CD8A, MAL

简单描述：Rabbit Polyclonal CD8A (Cytotoxic- & Suppressor T-Cell Marker) Antibody - Without BSA and Azide. Validated for use in IF, FC.

详情：FunctionIdentifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains.Cellular_LocationIsoform 1: Cell membrane; Single-pass type I membrane protein

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