KRT18 / CK18 / Cytokeratin 18 Antibody (clone AT2G3) | LM20563 | Leading Biology

商品分类：单克隆抗体

产品概述：Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.

靶点/蛋白：Human KRT18 / Cytokeratin 18

来源：Mouse

参考文献：Oshima R.G.,et al.Differentiation 33:61-68(1986).Kim J.W.,et al.Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.Kalnine N.,et al.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.Kulesh D.A.,et al.Mol. Cell. Biol. 8:1540-1550(1988).

特异性：Human

别名：Keratin, type I cytoskeletal 18, Cell proliferation-inducing gene 46 protein, Cytokeratin-18, CK-18, Keratin-18, K18, KRT18, CYK18

应用：IF (1:500), IHC-P (10 μg/ml), WB (1:1000)

简单描述：Mouse Monoclonal KRT18 / CK18 / Cytokeratin 18 Antibody (clone AT2G3). Validated for use in WB, IHC-P, IF, E. Clone: AT2G3.

详情：FunctionInvolved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.Cellular_LocationCytoplasm, perinuclear region. Nucleus, nucleolusTissue_LocationExpressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.

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