C1q Antibody (Subunit C) | LM18626 | Leading Biology

商品分类：单克隆抗体

产品概述：The complement component C1 is a protein complex that consists of six subunits of C1q. Each C1q subunit of the complex is known to bind to immune complexes, which often are deposited in basement membrane. C1q is a versatile recognition protein that triggers activation of the classical pathway of complement, where the first step involves the binding of the globular domain of Clq to the Fc regions of aggregated IgG or IgM. The C1q globular domain is a heterotrimer of the C-terminal halves of one A, one B, and one C chain, held together mainly by non-polar interactions, with a Ca2+ ion bound at the top. A modular organization has been suggested of the globular domain, consistent with the view that A, B, and C chains are functionally autonomous modules and have distinct and differential ligand-binding properties (1-3).

靶点/蛋白：A synthetic peptide corresponding to residues in human C1q (subunit C) was used as an immunogen.

来源：Rabbit

存储溶液：50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

参考文献：1. J F Bohnsack, et al. Proc Natl Acad Sci 82(11):3824- 3828, 1985
2. Gaboriaud C, et al. J Biol Chem. 278(47):46974-82, 2003
3. KOJOUHAROVA M S, et al. The Journal of immunology 172(7), 4351-4358, 2004


特异性：Human

别名：Complement C1q subcomponent subunit C, C1QC, C1QG

应用：WB~~1:1000~10000IHC~~1:100~250

简单描述：Rabbit Monoclonal C1q Antibody (Subunit C). Validated for use in WB, IHC. Clone: EPR2984Y.

详情：FunctionC1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.Cellular_LocationSecreted.

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