Anti-Human Thyroid Stimulating Hormone Receptor Antibody, clone 2C11 | LM18563 | Leading Biology

商品分类：单克隆抗体

靶点/蛋白：Mouse anti-Human thyroid stimulating hormone receptor antibody, clone 2C11 recognizes the human thyroid stimulating hormone receptor (TSHR) otherwise known as the thyrotropin receptor. TSHR is an important molecule in controlling the growth and function of the normal thyroid.Mouse anti-Human thyroid stimulating receptor antibody recognises both native and denatured TSH receptor (binding to an epitope at the carboxy terminus between amino acids 354 and 359). It does inhibit binding of TSH. No cross reactivity has been observed with related LH and FSH receptors.Clone 2C11 recognises the mutant TSH receptor known as I167N as well as the wild type molecule (Costagliolaet al.1998)

来源：Mouse

参考文献：1. Shepherd PS et al. (1999) Identification of an important thyrotrophin binding site on the human thyrotrophin receptor using monoclonal antibodies.Mol Cell Endocrinol. 149 (1-2): 197-206. 2. Costagliola, S. et al. (1998) Genetic immunization against the human thyrotropin receptor causes thyroiditis and allows production of monoclonal antibodies recognizing the native receptor.J Immunol. 160 (3): 1458-65. 3. Haas, A.K. et al. (2011) Mutations that silence constitutive signaling activity in the allosteric ligand-binding site of the thyrotropin receptor. Cell Mol Life Sci. 68: 159-167. 4. Frenzel, R. et al. (2006) The human thyrotropin receptor is predominantly internalized by beta-arrestin 2.Endocrinology. 147: 3114-22. 5. Akeno, N. et al. (2011) IFN-{alpha} Mediates the Development of Autoimmunity both by Direct TissueToxicity and through Immune Cell Recruitment Mechanisms.J Immunol. 186: 4693-706. 6. Akamizu, T. et al. (1999) Characterization of recombinant monoclonal antithyrotropin receptor antibodies (TSHRAbs) derived from lymphocytes of patients with Graves' disease: epitope and binding study of two stimulatory TSHRAbs.Endocrinology. 140: 1594-601. 7. Chazenbalk, G.D. et al. (2004) Does thyrotropin cleave its cognate receptor?Endocrinology. 145: 4-10. 8. Chen, C.R. et al. (2003) Targeted restoration of cleavage in a noncleaving thyrotropin receptor demonstrates that cleavage is insufficient to enhance ligand-independent activity.Endocrinology. 144: 1324-30. 9. Ellerhorst, J.A. et al. (2006) Human melanoma cells express functional receptors for thyroid-stimulating hormone.Endocr Relat Cancer. 13: 1269-77. 10. Li, Y.S. et al. (2004) Transgenic mice producing major histocompatibility complex class II molecules on thyroid cells do not develop apparent autoimmune thyroid diseases.Endocrinology. 145: 2524-30. 11. Neumann, S. et al. (2011) A new small-molecule antagonist inhibits Graves' disease antibody activation of the TSH receptor.J Clin Endocrinol Metab. 96: 548-54. 12. Narumi S et al. (2011) Nonclassic TSH resistance: TSHR mutation carriers with discrepantly high thyroidal iodine uptake.J Clin Endocrinol Metab. 96 (8): E1340-5. 13. Allen, M.D. et al. (2011) Occupancy of both sites on the thyrotropin (TSH) receptor dimer is necessary for phosphoinositide signaling.FASEB J. 25: 3687-94.

特异性：Human

别名：Thyrotropin receptor, Thyroid-stimulating hormone receptor, TSH-R, TSHR, LGR3

简单描述：Mouse Monoclonal Anti-Human Thyroid Stimulating Hormone Receptor Antibody, clone 2C11 . Validated for use in WB, IHC-P, FC, E, IP. Clone: 2C11.

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