NKX2.2 (NeuroenDOC - rine & Ewing's Sarcoma Marker) Antibody - With BSA and Azide | LM18362 | Leading Biology

商品分类：单克隆抗体

产品概述：Expression of NKX2.2 has been found in neuroendocrine tumors of the gut, making it a potential marker for the study of gastrointestinal neuroendocrine tumors. More recently, NKX2.2 protein was identified as a target of EWS-FLI-1, the fusion protein specific to Ewing sarcoma, and was shown to be differentially upregulated in Ewing sarcoma on the basis of array-based gene expression analysis. It acts as a valuable marker for Ewing sarcoma, with a sensitivity of 93% and a specificity of 89%, and aids in the differential diagnosis of small round cell tumors.

靶点/蛋白：Human NKX2.2 recombinant protein

来源：Mouse

存储溶液：0.5 ml at 200ug/ml with BSA and azide

参考文献：1. Wang, Y.C. et al. (2009) Endocr Relat Cancer 16, 267-79.2. Yoshida A et. al. Am J Surg Pathol. 2012;36(7):993-9.

特异性：Human

别名：Homeobox protein Nkx-22, Homeobox protein NK-2 homolog B, NKX2-2, NKX22, NKX2B

简单描述：Mouse Monoclonal NKX2.2 (NeuroenDOC - rine & Ewing's Sarcoma Marker) Antibody - With BSA and Azide. Validated for use in WB, IHC, FC, IP, E. Clone: NX2/294.

详情：FunctionActs as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter (By similarity).Cellular_LocationNucleus {ECO:0000255|PROSITE- ProRule:PRU00108}

生物商城：http://www.annoron.com

办公电话：010-56256916

官方售后：400-965-8633

企业 QQ：3212874516、3198592576

地 址：北京大兴经济技术开发区(亦庄)同济中路7号兴盛国际A栋4层