Tyrosinase (Melanoma Marker) Antibody - With BSA and Azide | LM16086 | Leading Biology

商品分类：单克隆抗体

产品概述：Recognizes a cluster of proteins between 70-80kDa, identified as tyrosinase. Occasionally a minor band at 55kDa is also detected. This MAb shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway; the hydroxylation of tyrosine to L-3,4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Staining of melanomas with this MAb shows tyrosinase in melanotic as well as amelanotic variants. This MAb is a useful marker for melanocytes and melanomas.

来源：Mouse

参考文献：Korner, A., et al. 1982. Mammalian tyrosinase catalyzes three reactions in the biosynthesis of melanin. Science 217: 1163-1165. | Hearing, V.J., et al. 1987. Mammalian tyrosinase—the critical regulatory control point in melanocyte pigmentation. Int. J. Biochem. 19: 1141-1147

特异性：Human

别名：Tyrosinase, 1.14.18.1, LB24-AB, Monophenol monooxygenase, SK29-AB, Tumor rejection antigen AB, TYR

简单描述：Mouse Monoclonal Tyrosinase (Melanoma Marker) Antibody - With BSA and Azide. Validated for use in IHC-P, IF, FC, E. Clone: OCA1/812.

详情：FunctionThis is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone.Cellular_LocationMelanosome membrane; Single-pass type I membrane protein

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