TGF-beta (Transforming Growth Factor beta) Antibody - With BSA and Azide | LM16043 | Leading Biology

商品分类：单克隆抗体

产品概述：This MAb recognizes TGF beta 1, 2 and 3. Three TGFī ?s have been identified in mammals. TGFī ?1, TGFī ?2 and TGFī ?3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecules. Biologically active TGFī ? requires dimerization of the monomers (usually homodimers) and release of the latent peptide portion. Overall, the mature region of the TGFī ?3 protein has approximately 80% identity to the mature region of both TGFī ?1 and TGFī ?2. However, the NH2 terminals or precursor regions of their molecules share only 27% sequence identity. TGFī ?ā€?s inhibit the growth of epithelial cells and stimulate the growth of mesenchymal cells.ā

来源：Mouse

参考文献：Dasch JR, Pace DR, Waegell W, Inenaga D, Ellingsworth L. Monoclonal antibodies recognizing transforming growth factor-beta. Bioactivity neutralization and transforming growth factor beta 2 affinity purification. J Immunol. 1989 Mar 1;142(5):1536-41

特异性：Human, Mouse, Hamster, Monkey, Cow, Dog

别名：Transforming growth factor beta-1, TGF-beta-1, Latency-associated peptide, LAP, TGFB1, TGFB

简单描述：Mouse Monoclonal TGF-beta (Transforming Growth Factor beta) Antibody - With BSA and Azide. Validated for use in ' + item.application + '. Clone: 1D11.16.8.

详情：FunctionMultifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts.Cellular_LocationSecreted, extracellular space, extracellular matrixTissue_LocationHighly expressed in bone. Abundantly expressed in articular cartilage and chondrocytes and is increased in osteoarthritis (OA). Colocalizes with ASPN in chondrocytes within OA lesions of articular cartilage.

生物商城：http://www.annoron.com

办公电话：010-56256916

官方售后：400-965-8633

企业 QQ：3212874516、3198592576

地 址：北京大兴经济技术开发区(亦庄)同济中路7号兴盛国际A栋4层