CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody - With BSA and Azide | LM14916 | Leading Biology

商品分类：单克隆抗体

产品概述：At least five CD1 genes (CD1a, b, c, d, and e) are identified. CD1 proteins have been demonstrated to restrict T cell response to non-peptide lipid and glycolipid antigens and play a role in non-classical antigen presentation. CD1a is a non-polymorphic MHC Class 1 related cell surface glycoprotein, expressed in association with Beta-2 microglobulin. Anti-CD1a labels Langerhans cell histiocytosis (Histiocytosis X), extranodal histiocytic sarcoma, a subset of T-lymphoblastic lymphoma/leukemia, and interdigitating dendritic cell sarcoma of the lymph node. When combined with antibodies against TTF-1 and CD5, anti-CD1a is useful in distinguishing between pulmonary and thymic neoplasms since CD1a is consistently expressed in thymic lymphocytes in both typical and atypical thymomas, but only focally in 1/6 of thymic carcinomas and not in lymphocytes in pulmonary neoplasms. Anti-CD1a is reported to be a new marker for perivascular epithelial cell tumor (PEComa).

靶点/蛋白：Human thymus cells

来源：Mouse

存储溶液：0.5 ml at 200ug/ml with BSA and azide

参考文献：1. McNally, AK. et al. 2011. Exp. Mol. Pathol. 91: 673-681. 2. Matsuda, A. et al. 2009. Invest. Ophthalmol. Vis. Sci. 50: 2871-2877. 3. Gulubova, M. et al. 2008. Clin. Exp. Metastasis. 25: 777-785. 4. Cassaday, RD. et al. 2007. Clin. Cancer Res. 13: 540-549.

特异性：Human

别名：T-cell surface glycoprotein CD1a, T-cell surface antigen T6/Leu-6, hTa1 thymocyte antigen, CD1a, CD1A

简单描述：Mouse Monoclonal CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody - With BSA and Azide. Validated for use in WB, IHC, IF, FC, IP, E. Clone: O10.

详情：FunctionAntigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.Cellular_LocationCell membrane; Single-pass type I membrane protein. Endosome membrane. Note=Subject to intracellular trafficking between the cell membrane and endosomes. Localizes to cell surface lipid raftsTissue_LocationExpressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on certain T-cell leukemias, and in various other tissues.

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企业 QQ：3212874516、3198592576

地 址：北京大兴经济技术开发区(亦庄)同济中路7号兴盛国际A栋4层