CD14 (Monocyte / Macrophage Marker) Antibody - Without BSA and Azide | LM14887 | Leading Biology

商品分类：单克隆抗体

产品概述：Recognizes a protein of 55kDa, identified as CD14 (also known lipopolysaccharide receptor). CD14 is expressed strongly on monocytes and macrophage and weakly on the surface of neutrophils. CD14 is anchored to cells by linkage to glycosylphosphatidylinositol (GPI) and functions as a high affinity receptor for complexes of LPS and LPS binding protein (LBP). Soluble CD14, also binding to LPS, acts at physiological concentration as an LPS agonist and has, at higher concentrations, an LPS antagonizing effect in cell activation.

来源：Mouse

参考文献：Schumann, R.R. 1992. Function of lipopolysaccharide (LPS)-binding protein (LBP) and CD14, the receptor for LPS/LBP complexes: a short review. Res. Immunol. 143: 11-15. | Simmons, D.L., et al. 1989. Monocyte antigen CD14 is a phospholipid anchored membrane protein. Blood 73: 284-289

特异性：Human

别名：Monocyte differentiation antigen CD14, Myeloid cell-specific leucine-rich glycoprotein, CD14, Monocyte differentiation antigen CD14, urinary form, Monocyte differentiation antigen CD14, membrane-bound form, CD14

简单描述：Mouse Monoclonal CD14 (Monocyte / Macrophage Marker) Antibody - Without BSA and Azide. Validated for use in IF, FC. Clone: LPSR/927.

详情：FunctionIn concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the MD-2/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules.Cellular_LocationCell membrane; Lipid-anchor, GPI-anchor.Tissue_LocationExpressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages

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