N-Cadherin Antibody (Clone # EPR1791-4) | LM12591 | Leading Biology

商品分类：单克隆抗体

产品概述：Thy1 is a GPI-anchored, developmentally regulated protein involved in various signaling cascades that mediate neurite outgrowth, T cell activation, tumor suppression, apoptosis, and fibrosis. It is highly expressed on the surface of adult neurons and is thought to play a role in modulating adhesive and migratory events, such as neurite extension. Decreased Thy1 expression is associated with the development of epithelial ovarian cancer, revealing its role as a putative tumor suppressor gene of human ovarian cancer. Thy1 knockout mice have impaired cutaneous immune responses and abnormal retinal development. Thy1 is epigenetically regulated or deregulated in some disease states, such as pulmonary fibrosis. The potentially reversible hypermethylation of the Thy1 promoter offers the possibility of novel therapeutic options in this disease.

靶点/蛋白：N-Cadherin

来源：Rabbit

特异性：Human, Mouse

别名：CDH2, CDHN, NCAD, Cadherin-2, CDw325

简单描述：Rabbit Monoclonal N-Cadherin Antibody (Clone # EPR1791-4). Validated for use in WB. Clone: EPR1791-4.

详情：FunctionCadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity).Cellular_LocationCell membrane; Single-pass type I membrane protein

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企业 QQ：3212874516、3198592576

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