KLF4 Antibody (aa1-170, clone AT4E6) | LM12361 | Leading Biology

商品分类：单克隆抗体

产品概述：Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription.

来源：Mouse

参考文献：Yet S.-F.,et al.J. Biol. Chem. 273:1026-1031(1998).Foster K.W.,et al.Cell Growth Differ. 10:423-434(1999).Camacho-Vanegas O.,et al.FASEB J. 27:432-436(2013).Garrett-Sinha L.A.,et al.Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases.Ota T.,et al.Nat. Genet. 36:40-45(2004).

特异性：Human

别名：Krueppel-like factor 4, Epithelial zinc finger protein EZF, Gut-enriched krueppel-like factor, KLF4, EZF, GKLF

应用：IHC-P (20 μg/ml), WB (1:1000-1:2000),

简单描述：Mouse Monoclonal KLF4 Antibody (aa1-170, clone AT4E6). Validated for use in WB, IHC-P, E. Clone: AT4E6.

详情：FunctionTranscription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription.Cellular_LocationNucleus.

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