Functional TRAIL-R2 (human) Antibody, mAb(preservative free) | LM12138 | Leading Biology

商品分类：单克隆抗体

产品概述：TRAIL-R2 is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa.

靶点/蛋白：Recognizes human TRAIL-R2. Does not cross-react with human TRAIL-R1, -R3 or -R4.

来源：Purified From Concentrated Hybridoma Tissue Culture Supernatant.

存储溶液：Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.

特异性：Human

别名：TRAIL Receptor 2; DR5; KILLER; TNFRSF10B; CD262

简单描述：Purified From Concentrated Hybridoma Tissue Culture Supernatant. Monoclonal Functional TRAIL-R2 (human) Antibody, mAb(preservative free). Validated for use in IHC-P, FC, ICC, IP. Clone: HS201.

详情：FunctionReceptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B. Essential for ER stress-induced apoptosis.Cellular_LocationMembrane; Single-pass type I membrane proteinTissue_LocationWidely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain

生物商城：http://www.annoron.com

办公电话：010-56256916

官方售后：400-965-8633

企业 QQ：3212874516、3198592576

地 址：北京大兴经济技术开发区(亦庄)同济中路7号兴盛国际A栋4层