Estrogen Receptor, alpha (Marker of Estrogen Dependence) Mouse Monoclonal Antibody [Clone ER506] | LM12033 | Leading Biology

商品分类：单克隆抗体

靶点/蛋白：Recombinant human Estrogen Receptor alpha protein (aa2-185)

来源：Mouse

存储溶液：0.5ml at 100ug/ml with BSA and azide

参考文献：1. Zafrani B, et. al. Histopathology 2000; 37(6), 536–545.2. Harvey JM, et. al. Journal of Clinical Oncology 1999; 17(5), 1474–1481.

特异性：Human

别名：Estrogen Receptor alpha delta 4*5, 6, 7*/654 isoform; Estrogen Receptor alpha delta 4 +49 isoform; Nuclear receptor subfamily 3 group A member 1

简单描述：Mouse Monoclonal Estrogen Receptor, alpha (Marker of Estrogen Dependence) Mouse Monoclonal Antibody [Clone ER506]. Validated for use in IF, FC. Clone: ER506.

详情：FunctionNuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA- binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF- kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA- binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Isoform 3 is involved in activation of NOS3 and endothelial nitric oxide production. Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full length receptor. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3. Isoform 3 can bind to ERE and inhibit isoform 1.Cellular_LocationIsoform 1: Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407, ECO:0000269|PubMed:12682286}. Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=A minor fraction is associated with the inner membrane Nucleus. Golgi apparatus. Cell membrane. Note=Colocalizes with ZDHHC7 and ZDHHC21 in the Golgi apparatus where most probably palmitoylation occurs. Associated with the plasma membrane when palmitoylatedTissue_LocationWidely expressed. Isoform 3 is not expressed in the pituitary gland.

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